o-Methylcinnamic acid → (E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-o-tolyl-acrylamide

HRID 2065210Notes

Reaction equation

HRID 2065210 reaction equation
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[C:15]1([CH3:26])[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1/[CH:21]=[CH:22]/[C:23](O)=[O:24]>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH:12][C:23](=[O:24])/[CH:22]=[CH:21]/[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[CH3:26])=[N:8]1

Participants

3

Reactant 2

HCID 819020o-Methylcinnamic acidHCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

Product 1

HCID 66929495(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-o-tolyl-acrylamide

Procedure

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-o-tolyl-acrylic acid. LC-MS-conditions 05b: tR=1.12 min; [M+H]+=348.28.

Sources & evidence

ORD record
ord-9e380a5c742e4f86b4d379b738c8a72c
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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