2-methyl-5-phenyl-1,3-thiazole-4-carboxylic Acid → HCID 66929188, compound

HRID 2065221Notes

Reaction equation

HRID 2065221 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:6]CCO1.[CH3:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:21]([C:23](O)=[O:24])[N:22]=1>>[O:6]=[C:2]([CH3:1])[CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([NH:16][C:23]([C:21]2[N:22]=[C:18]([CH3:17])[S:19][C:20]=2[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[O:24])[CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 9435352-methyl-5-phenyl-1,3-thiazole-4-carboxylic AcidHCID 669287261-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine

Product 1

HCID 66929188HCID 66929188, compound

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine and 2-methyl-5-phenyl-thiazole-4-carboxylic acid. LC-MS-conditions 01: tR=0.94 min; [M+H]+=383.10.

Sources & evidence

ORD record
ord-6f76ebd47614468b82f794b3c6a71a1d
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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