4-Methylcinnamic Acid → HCID 66929621, compound

HRID 2065235Notes

Reaction equation

HRID 2065235 reaction equation
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[C:17]1([CH3:28])[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[C:25](O)=[O:26])=[CH:19][CH:18]=1>>[F:4][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[C:14]([NH:16][C:25](=[O:26])/[CH:24]=[CH:23]/[C:20]3[CH:21]=[CH:22][C:17]([CH3:28])=[CH:18][CH:19]=3)[CH:13]=[N:12]2)=[CH:7][CH:6]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 7317674-Methylcinnamic AcidHCID 669285491-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine

Product 1

HCID 66929621HCID 66929621, compound

Procedure

Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-p-tolyl-acrylic acid. LC-MS-conditions 05b: tR=1.10 min; [M+H]+=372.18.

Sources & evidence

ORD record
ord-feb095ed8cfd40bcaae2f7f016e210ca
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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