HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-fluorocinnamic acid → (E)-3-(2-Chloro-4-fluoro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-fluorocinnamic acid | HCID 6257297 | — |
| Reactant | 1-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine | HCID 66928549 | — |
| Product | (E)-3-(2-Chloro-4-fluoro-phenyl)-N-{1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-yl}-acrylamide | HCID 66929430 | — |
Reaction Steps
Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(2-chloro-4-fluoro-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.12 min; [M+H]+=410.06.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288419B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9d49f6e8ad6c450390b95815d735ec78 |
| Source note | uspto-grants-2012_10 |