m-(Trifluoromethyl)cinnamic acid → HCID 66928897, compound

HRID 2065240Notes

Reaction equation

HRID 2065240 reaction equation
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[F:17][C:18]([F:31])([F:30])[C:19]1[CH:20]=[C:21](/[CH:25]=[CH:26]/[C:27](O)=[O:28])[CH:22]=[CH:23][CH:24]=1>>[F:4][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH:16][C:27](=[O:28])/[CH:26]=[CH:25]/[C:21]3[CH:22]=[CH:23][CH:24]=[C:19]([C:18]([F:30])([F:31])[F:17])[CH:20]=3)=[N:12]2)=[CH:7][CH:6]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 719451m-(Trifluoromethyl)cinnamic acidHCID 669293691-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 66928897HCID 66928897, compound

Procedure

Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(3-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.15 min; [M+H]+=425.99.

Sources & evidence

ORD record
ord-625242d7d48c4f938d871472896783a5
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

Loading…