2-Fluoro-3-(trifluoromethyl)cinnamic acid → HCID 86650892, compound

HRID 2065249Notes

Reaction equation

HRID 2065249 reaction equation
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[F:17][C:18]1[C:23]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:21]=[CH:20][C:19]=1/[CH:28]=[CH:29]/[C:30](O)=[O:31]>>[F:4][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH:16][C:30](=[O:31])/[CH:29]=[CH:28]/[C:19]3[CH:20]=[CH:21][CH:22]=[C:23]([C:24]([F:26])([F:25])[F:27])[C:18]=3[F:17])=[N:12]2)=[CH:7][CH:6]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 57028922-Fluoro-3-(trifluoromethyl)cinnamic acidHCID 669293691-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 86650892HCID 86650892, compound

Procedure

Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(2-fluoro-3-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.16 min; [M+H]+=443.98.

Sources & evidence

ORD record
ord-3d0b7930a24a4a88b99ca361d67ffad8
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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