5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid → 5-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide

HRID 2065256Notes

Reaction equation

HRID 2065256 reaction equation
[F:1][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].[CH3:17][O:18][C:19]1[CH:20]=[C:21]([C:25]2[O:29][C:28]([CH3:30])=[N:27][C:26]=2[C:31](O)=[O:32])[CH:22]=[CH:23][CH:24]=1>>[F:4][C:2]([C:5]1[O:9][C:8]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH:16][C:31]([C:26]3[N:27]=[C:28]([CH3:30])[O:29][C:25]=3[C:21]3[CH:22]=[CH:23][CH:24]=[C:19]([O:18][CH3:17])[CH:20]=3)=[O:32])=[N:12]2)=[CH:7][CH:6]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 669292245-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acidHCID 669293691-[5-(1,1-Difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 669294705-(3-Methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid {1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-yl}-amide

Procedure

Following general procedure B, starting from 1-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and 5-(3-methoxy-phenyl)-2-methyl-oxazole-4-carboxylic acid. LC-MS-conditions 05b: tR=1.18 min; [M+H]+=443.0.

Sources & evidence

ORD record
ord-df2984ba265c4829858927b18a10ed7f
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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