HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(2,5-difluoro-4-methoxy-phenyl)-acrylic acid → (E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,5-difluoro-4-methoxy-phenyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(2,5-difluoro-4-methoxy-phenyl)-acrylic acid | HCID 5928340 | — |
| Reactant | 1-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine | HCID 66928611 | — |
| Product | (E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-3-(2,5-difluoro-4-methoxy-phenyl)-acrylamide | HCID 66929048 | — |
Reaction Steps
Following general procedure B followed by T, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(2,5-difluoro-4-methoxy-phenyl)-acrylic acid. LC-MS-conditions 01b: tR=0.86 min; [M+H]+=402.17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288419B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-743d55fd9aa04e5f94692c82327cccb8 |
| Source note | uspto-grants-2012_10 |