1-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine → HCID 66929564, compound

HRID 2065287Notes

Reaction equation

HRID 2065287 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[Cl:19][C:20]1[C:25]([F:26])=[CH:24][C:23](/[CH:27]=[CH:28]/[C:29](O)=[O:30])=[CH:22][C:21]=1[F:32]>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:29](=[O:30])/[CH:28]=[CH:27]/[C:23]3[CH:24]=[C:25]([F:26])[C:20]([Cl:19])=[C:21]([F:32])[CH:22]=3)=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 669287811-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamineHCID 66929089HCID 66929089, compound

Product 1

HCID 66929564HCID 66929564, compound

Procedure

Following general procedure B followed by T, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(4-chloro-3,5-difluoro-phenyl)-acrylic acid. LC-MS-conditions 01b: tR=0.97 min; [M+H]+=406.11.

Sources & evidence

ORD record
ord-368d31357fe649cb933d76d5ef7535da
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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