1-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine → HCID 66929178, compound

HRID 2065288Notes

Reaction equation

HRID 2065288 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[F:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[C:23]([F:30])=[CH:22][C:21]=1/[CH:31]=[CH:32]/[C:33](O)=[O:34]>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[C:16]([NH:18][C:33](=[O:34])/[CH:32]=[CH:31]/[C:21]3[CH:22]=[C:23]([F:30])[C:24]([C:26]([F:27])([F:29])[F:28])=[CH:25][C:20]=3[F:19])[CH:15]=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 669286111-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamineHCID 66929036(2E)-3-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-2-propenoic acid

Product 1

HCID 66929178HCID 66929178, compound

Procedure

Following general procedure B followed by T, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(2,5-difluoro-4-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 01b: tR=0.97 min; [M+H]+=440.1.

Sources & evidence

ORD record
ord-af2f145a1d9c421dab645496cf6e7ac5
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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