4-(Trifluoromethyl)cinnamic acid → (E)-N-[1-(6-Acetyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide
Reaction equation
[CH3:1][C:2]1([C:7]2[N:12]=[C:11]([CH2:13][N:14]3[CH:18]=[C:17]([NH2:19])[CH:16]=[N:15]3)[CH:10]=[CH:9][CH:8]=2)[O:6]CCO1.[F:20][C:21]([F:34])([F:33])[C:22]1[CH:27]=[CH:26][C:25](/[CH:28]=[CH:29]/[C:30](O)=[O:31])=[CH:24][CH:23]=1>>[C:2]([C:7]1[N:12]=[C:11]([CH2:13][N:14]2[CH:18]=[C:17]([NH:19][C:30](=[O:31])/[CH:29]=[CH:28]/[C:25]3[CH:24]=[CH:23][C:22]([C:21]([F:33])([F:34])[F:20])=[CH:27][CH:26]=3)[CH:16]=[N:15]2)[CH:10]=[CH:9][CH:8]=1)(=[O:6])[CH3:1]Participants
3
Procedure
Following general procedure B followed by C, starting from 1-[6-(2-methyl-[1,3]dioxolan-2-yl)-pyridin-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 02: tR=1.02 min; [M+H]+=414.95.
Sources & evidence
- ORD record
- ord-eaf2dcd9cf644f46a0dd6fa45c157d89
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288419B2
Reaction notes
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