HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)cinnamic acid → (E)-N-[1-(2-Acetyl-thiazol-5-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)cinnamic acid | HCID 688070 | — |
| Reactant | 1-[2-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-5-ylmethyl]-1H-pyrazol-4-ylamine | HCID 66929332 | — |
| Product | (E)-N-[1-(2-Acetyl-thiazol-5-ylmethyl)-1H-pyrazol-4-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide | HCID 66929009 | — |
Reaction Steps
Following general procedure B followed by C, starting from 1-[2-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-5-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 02: tR=1.01 min; [M+H]+=420.83.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288419B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a968fc861aed4da2abb6adbd1f572b2e |
| Source note | uspto-grants-2012_10 |