4-(Trifluoromethyl)cinnamic acid → HCID 66929522, compound

HRID 2065378Notes

Reaction equation

HRID 2065378 reaction equation
[CH3:1][C:2]1([C:7]2[N:8]=[C:9]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)[S:10][CH:11]=2)[O:6]CCO1.[F:19][C:20]([F:33])([F:32])[C:21]1[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29](O)=[O:30])=[CH:23][CH:22]=1>>[C:2]([C:7]1[N:8]=[C:9]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:29](=[O:30])/[CH:28]=[CH:27]/[C:24]3[CH:23]=[CH:22][C:21]([C:20]([F:32])([F:33])[F:19])=[CH:26][CH:25]=3)=[N:14]2)[S:10][CH:11]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 6880704-(Trifluoromethyl)cinnamic acidHCID 669289951-[4-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 66929522HCID 66929522, compound

Procedure

Following general procedure B followed by C, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 05: tR=0.86 min; [M+H]+=420.88.

Sources & evidence

ORD record
ord-52374fa673ad4363a3353fc165b9c5a9
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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