3-(Trifluoromethoxy)cinnamic Acid → (E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide
Reaction equation
[CH3:1][C:2]1([C:7]2[N:8]=[C:9]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)[S:10][CH:11]=2)[O:6]CCO1.[F:19][C:20]([F:34])([F:33])[O:21][C:22]1[CH:23]=[C:24](/[CH:28]=[CH:29]/[C:30](O)=[O:31])[CH:25]=[CH:26][CH:27]=1>>[C:2]([C:7]1[N:8]=[C:9]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:30](=[O:31])/[CH:29]=[CH:28]/[C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([O:21][C:20]([F:33])([F:34])[F:19])[CH:23]=3)=[N:14]2)[S:10][CH:11]=1)(=[O:6])[CH3:1]Participants
3
Procedure
Following general procedure B followed by C, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(3-trifluoromethoxy-phenyl)-acrylic acid. LC-MS-conditions 05: tR=0.87 min; [M+H]+=436.88.
Sources & evidence
- ORD record
- ord-faa25ee5b20f49edb03c7da590e091b9
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288419B2
Reaction notes
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