5-Phenyl-1,3-oxazole-4-carboxylic acid → 5-Phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-oxazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide

HRID 2065384Notes

Reaction equation

HRID 2065384 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][C:8]2[O:9][CH:10]=[C:11]([C:13](=[O:15])[CH3:14])[N:12]=2)[N:3]=1.[C:16]1([C:22]2[O:26][CH:25]=[N:24][C:23]=2[C:27](O)=[O:28])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:13]([C:11]1[N:12]=[C:8]([CH2:7][N:4]2[CH:5]=[CH:6][C:2]([NH:1][C:27]([C:23]3[N:24]=[CH:25][O:26][C:22]=3[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[O:28])=[N:3]2)[O:9][CH:10]=1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 27762995-Phenyl-1,3-oxazole-4-carboxylic acidHCID 669290971-[2-(3-Amino-pyrazol-1-ylmethyl)-oxazol-4-yl]-ethanone

Product 1

HCID 426299625-Phenyl-oxazole-4-carboxylic acid [1-(4-acetyl-oxazol-2-ylmethyl)-1H-pyrazol-3-yl]-amide

Procedure

Following general procedure B, starting from 1-[2-(3-amino-pyrazol-1-ylmethyl)-oxazol-4-yl]-ethanone and 5-phenyl-oxazole-4-carboxylic acid. LC-MS-conditions 01: tR=0.88 min; [M+H]+=377.95.

Sources & evidence

ORD record
ord-f080e54715104398877a805256141aed
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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