5-Phenyl-1,3-oxazole-4-carboxylic acid → HCID 66929131, compound

HRID 2065385Notes

Reaction equation

HRID 2065385 reaction equation
[F:1][C:2]([C:5]1[N:6]=[C:7]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)[S:8][CH:9]=1)([F:4])[CH3:3].[C:17]1([C:23]2[O:27][CH:26]=[N:25][C:24]=2[C:28](O)=[O:29])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:1][C:2]([C:5]1[N:6]=[C:7]([CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH:16][C:28]([C:24]3[N:25]=[CH:26][O:27][C:23]=3[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:29])=[N:12]2)[S:8][CH:9]=1)([F:4])[CH3:3]

Participants

3

Reactant 2

HCID 27762995-Phenyl-1,3-oxazole-4-carboxylic acidHCID 66928857HCID 66928857, compound

Product 1

HCID 66929131HCID 66929131, compound

Procedure

Following general procedure B, 1-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-1H-pyrazol-3-ylamine and 5-phenyl-oxazole-4-carboxylic acid. LC-MS-conditions 02: tR=1.04 min; [M+H]+=415.86.

Sources & evidence

ORD record
ord-366ab45a6609426a9e9622b5f45010ec
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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