3-Indoleacrylic acid → HCID 66929137, compound

HRID 2065387Notes

Reaction equation

HRID 2065387 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21](/[CH:28]=[CH:29]/[C:30](O)=[O:31])=[CH:20]1>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[C:16]([NH:18][C:30](=[O:31])/[CH:29]=[CH:28]/[C:21]3[C:22]4[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=4)[NH:19][CH:20]=3)[CH:15]=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 53750483-Indoleacrylic acidHCID 669286111-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine

Product 1

HCID 66929137HCID 66929137, compound

Procedure

Following general procedure B followed by C, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-4-ylamine and (E)-3-(1H-indol-3-yl)-acrylic acid. LC-MS-conditions 05b: tR=0.84 min; [M+H]+=375.31.

Sources & evidence

ORD record
ord-e802a0cf967a4a9ba4aeaa6118f12b93
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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