Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropyl Acetate | HCID 7915 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Benzyl-2-piperidone | HCID 5170076 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67094508 | HCID 67094508 | — |
Reaction Steps
10.00 kg (52.84 mol) 1-benzylpiperidone (K) were taken and 9.21 kg (105.68 mol) morpholine (L) and 30.0 L isopropylacetate were added. Then the reaction mixture obtained was heated to reflux temperature (95° C.) using the water separator and stirred until no more water separated off. Then the mixture was hydrogenated at 4 bar and at an internal temperature of 60° C. in the presence of 0.50 kg Raney nickel catalyst. Then the solvent was completely distilled off in vacuo. Then 45.0 L ethanol were added and 10.87 kg (116.25 mol) ethanolic 10-mol hydrochloric acid were metered in. The resulting suspension was cooled to 20° C. and stirred for 30 minutes at 20° C. The product was centrifuged off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288531B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-6063ba182b73440a82986bb9f4d38638 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
