Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Benzyl-2-piperidone | HCID 5170076 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67094508 | HCID 67094508 | — |
Reaction Steps
10.00 kg (52.84 mol) 1-benzylpiperidone (K) were taken and 9.21 kg (105.68 mol) morpholine (L) as well as 50.0 L toluene were added. Then the reaction mixture obtained was heated to reflux temperature using the water separator (110° C.) and stirred until no more water separated off. Then the mixture was hydrogenated at 4 bar and an internal temperature of 60° C. in the presence of 0.50 kg Raney nickel catalyst in 6 L ethanol. The catalyst was separated off and washed with 20 L ethanol. Then the solvent was distilled off completely in vacuo. Then 80.0 L ethanol were added and at 50° C. 16.05 kg (132.10 mol) hydrochloric acid (30%) were metered in. The resulting suspension was cooled to 20° C. and stirred for 30 minutes at 20° C. The product was centrifuged off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288531B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-f501e89ee4d94fbf8aecec4f4939ad3c |
|---|
| Source note | uspto-grants-2012_10 |
|---|
