HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2065565Generated: October 31, 2026
Diethyl Ether → Methyl 5-aminopyridine-2-carboxylate
https://huagongshe.com/reaction/2065565
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 5-Aminopyridine-2-carboxylic acid | HCID 4179726 | — |
| Solvent | Benzene methanol | HCID 21927730 | — |
| Product | Methyl 5-aminopyridine-2-carboxylate | HCID 12457877 | — |
Reaction Steps
5-Amino-pyridine-2-carboxylic acid 1 (5.4 mmol) is dissolved in benzene:MeOH 3:1 (40 mL) and cooled in an ice-bath to 0° C. To the solution is slowly added 2M TMSCH2N2 in Et2O solution (6.5 mmol). After the addition is complete, the reaction mixture is warmed to it and stirred for 6 h. After removing the solvent in vacuum, methyl 5-aminopicolinate 2 is obtained and used in the next step without further purification. MS (m/z) (M+1)+: 153.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08288540B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-acbe7153b961483f959434d93fe27ae3 |
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| Source note | uspto-grants-2012_10 |
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