HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 58171900, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]piperidine-2-carboxylic acid | HCID 581831 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | N5-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2-methyl-pyridine-3,5-diamine | HCID 58171954 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58171900 | HCID 58171900 | — |
Reaction Steps
To a solution of piperidine-1,2-dicarboxylic acid 1-tert-butyl ester (0.04 mmol) in DMF (1 mL) is added HATU (0.05 mmol) and DIEA (20.12 mmol). The resulting mixture is stirred for 2 min at rt and then N5-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2-methyl-pyridine-3,5-diamine 12 (0.032 mmol) is added. The reaction mixture is stirred at 45° C. for 12 h. The mixture is cooled down and directly purified by preparative LCMS to afford 2-{5-[5-(4-methoxy-phenyl)-pyrimidin-2-ylamino]-2-methyl-pyridin-3-ylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester 20. MS (m/z) (M+1)+: 519.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288540B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-19085a2006654b9f899ea3c47fb41f16 |
| Source note | uspto-grants-2012_10 |