HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dl-Tryptophan → 2-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dl-Tryptophan | HCID 1148 | — |
| Reactant | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| Product | 2-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid | HCID 45256702 | 42% |
Reaction Steps
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-tryptophan to provide the title compound in 42% yield as yellow needles (recrystallization from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-73afbdec5a5642eb980ff6e173105de3 |
| Source note | uspto-grants-2012_10 |