HuagongsheHuagongshe Chemistry Print Report · For research reference only
DL-norvaline → 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | DL-norvaline | HCID 824 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid | HCID 45256873 | 15% |
Reaction Steps
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-2-aminopentanoic acid to provide the title compound in 15% yield as yellow needles (flash chromatography on SiO2, eluent MeCN, H2O, AcOH-20, 1, 0.3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-fe506c4b218f493383546404080c7ff9 |
| Source note | uspto-grants-2012_10 |