4-Nitro-3-phenyl-L-alanine → HCID 45256879, compound

HRID 2065598Notes

Reaction equation

HRID 2065598 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[N+:16]([C:19]1[CH:30]=[CH:29][C:22]([CH2:23][C@@H:24]([C:26]([OH:28])=[O:27])[NH2:25])=[CH:21][CH:20]=1)([O-:18])=[O:17]>>[C:26]([C@@H:24]([NH:25][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:23][C:22]1[CH:21]=[CH:20][C:19]([N+:16]([O-:18])=[O:17])=[CH:30][CH:29]=1)([OH:28])=[O:27]

Participants

3

Reactant 2

HCID 137064-Nitro-3-phenyl-L-alanineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45256879HCID 45256879, compoundYield 61%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 4-nitro-L-phenylalanine to provide the title compound in 61% yield as yellow needles (recrystallization from MeOH/water).

Sources & evidence

ORD record
ord-71b8fc4bc7994e648eccb58d00ed158c
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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