phenylalaninol, (R)- → HCID 45257055, compound

HRID 2065599Notes

Reaction equation

HRID 2065599 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C@@H:17]([CH2:25][OH:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[Cl:15][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:16][C@@H:17]([CH2:25][OH:26])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:11]([C:12]([OH:14])=[O:13])=[CH:10]2

Participants

3

Reactant 2

HCID 853475phenylalaninol, (R)-HCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45257055HCID 45257055, compoundYield 22%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with D-phenylalaninol to provide the title compound in 22% yield as yellow needles (recrystallization from EtOH).

Sources & evidence

ORD record
ord-a026528347044c22b4b780dd1f4b1a22
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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