O-Methyl-L-Tyrosine → HCID 45254179, compound

HRID 2065605Notes

Reaction equation

HRID 2065605 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:29]=[CH:28][C:21]([CH2:22][C@@H:23]([C:25]([OH:27])=[O:26])[NH2:24])=[CH:20][CH:19]=1>>[C:25]([C@@H:23]([NH:24][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:22][C:21]1[CH:28]=[CH:29][C:18]([O:17][CH3:16])=[CH:19][CH:20]=1)([OH:27])=[O:26]

Participants

3

Reactant 2

HCID 2723935O-Methyl-L-TyrosineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254179HCID 45254179, compoundYield 60%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 4-methoxy-L-phenylalanine to provide the title compound in 60% yield as yellow needles (recrystallization from EtOH).

Sources & evidence

ORD record
ord-9d9fcfe4081142568dff735ff701543b
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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