5-Methyl-DL-tryptophan → HCID 45254183, compound

HRID 2065609Notes

Reaction equation

HRID 2065609 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH3:16][C:17]1[CH:31]=[C:30]2[C:20]([NH:21][CH:22]=[C:23]2[CH2:24][CH:25]([C:27]([OH:29])=[O:28])[NH2:26])=[CH:19][CH:18]=1>>[C:27]([CH:25]([NH:26][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:24][C:23]1[C:30]2[C:20](=[CH:19][CH:18]=[C:17]([CH3:16])[CH:31]=2)[NH:21][CH:22]=1)([OH:29])=[O:28]

Participants

3

Reactant 2

HCID 928525-Methyl-DL-tryptophanHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254183HCID 45254183, compoundYield 99%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 5-methyl-DL-tryptophan to provide the title compound in 99% yield as yellow needles (recrystallization from DMF/water).

Sources & evidence

ORD record
ord-4b42db2d672044c0b2f0b306ad32ba45
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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