O-benzyl-L-tyrosine → HCID 45254373, compound

HRID 2065610Notes

Reaction equation

HRID 2065610 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH2:16]([O:23][C:24]1[CH:35]=[CH:34][C:27]([CH2:28][C@@H:29]([C:31]([OH:33])=[O:32])[NH2:30])=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([O:23][C:24]1[CH:35]=[CH:34][C:27]([CH2:28][C@H:29]([NH:30][C:2]2[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=3)[N:3]=2)[C:31]([OH:33])=[O:32])=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 725701O-benzyl-L-tyrosineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254373HCID 45254373, compoundYield 32%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with O-benzyl-L-tyrosine to provide the title compound in 32% yield as yellow needles (recrystallization from acetone/EtOH).

Sources & evidence

ORD record
ord-3b2c531e367d438bb7eff6b1fa254dd7
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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