HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-L-phenylalanine → 2-[(S)-1-Carboxy-2-(4-chloro-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-L-phenylalanine | HCID 736190 | — |
| Reactant | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| Product | 2-[(S)-1-Carboxy-2-(4-chloro-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid | HCID 45254374 | 63% |
Reaction Steps
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 4-chloro-L-phenylalanine to provide the title compound in 63% yield as yellow needles (recrystallization from EtOH/water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-84110fc197884cbab92f772f9fde777c |
| Source note | uspto-grants-2012_10 |