2,6-Dichloroquinoline-3-carboxylic acid → HCID 178524030, compound

HRID 2065616Notes

Reaction equation

HRID 2065616 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7](Cl)[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([C:24]([OH:26])=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1>>[C:24]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1)([OH:26])=[O:25]

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 178510868HCID 178510868, compound

Product 1

HCID 178524030HCID 178524030, compoundYield 33%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-histidine to provide the title compound in 33% yield as yellow needles (recrystallization from DMF/water).

Sources & evidence

ORD record
ord-0940ee8371d14cebacde785a11ae9847
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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