L-Tyrosine → HCID 45254559, compound

HRID 2065619Notes

Reaction equation

HRID 2065619 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C@H:17]([C:26]([OH:28])=[O:27])[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1>>[C:26]([C@@H:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)([OH:28])=[O:27]

Participants

3

Reactant 2

HCID 6057L-TyrosineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254559HCID 45254559, compoundYield 71%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with L-tyrosine (2 eq.) to provide the title compound in 71% yield as yellow needles (recrystallization from acetone/water).

Sources & evidence

ORD record
ord-733790938f0c4bfd873000bd9444e484
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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