Levodopa → HCID 45254562, compound

HRID 2065621Notes

Reaction equation

HRID 2065621 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[OH:16][C:17]1[CH:18]=[C:19]([CH:26]=[CH:27][C:28]=1[OH:29])[CH2:20][C@@H:21]([C:23]([OH:25])=[O:24])[NH2:22]>>[C:23]([C@@H:21]([NH:22][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:20][C:19]1[CH:26]=[CH:27][C:28]([OH:29])=[C:17]([OH:16])[CH:18]=1)([OH:25])=[O:24]

Participants

3

Reactant 2

HCID 6047LevodopaHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254562HCID 45254562, compoundYield 50%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 3,4-dihydroxy-L-phenylalanine to provide the title compound in 50% yield as yellow needles (recrystallization from acetone/toluene).

Sources & evidence

ORD record
ord-2a99402c80344c6786b0b8bbe993b2bb
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

Loading…