p-Fluorophenylalanine → HCID 45254748, compound

HRID 2065623Notes

Reaction equation

Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[F:16][C:17]1[CH:28]=[CH:27][C:20]([CH2:21][CH:22]([C:24]([OH:26])=[O:25])[NH2:23])=[CH:19][CH:18]=1>>[C:24]([CH:22]([NH:23][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:20]1[CH:27]=[CH:28][C:17]([F:16])=[CH:18][CH:19]=1)([OH:26])=[O:25]

Participants

Reactant 2

HCID 4654p-Fluorophenylalanine

HCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45254748HCID 45254748, compoundYield 80%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 4-fluoro-DL-phenylalanine to provide the title compound in 80% yield as yellow needles.

Sources & evidence

ORD record: ord-1ece9fd1046a4809b15cd557f46e045e
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288549B2

Reaction notes

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