2-Fluorophenylalanine → HCID 131730020, compound

HRID 2065624Notes

Reaction equation

HRID 2065624 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[F:16][C:17]1[CH:28]=[CH:27][CH:26]=[CH:25][C:18]=1[CH2:19][CH:20]([C:22]([OH:24])=[O:23])[NH2:21]>>[NH4+:3].[C:22]([CH:20]([NH:21][C:2]1[C:11]([C:12]([O-:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:19][C:18]1[CH:25]=[CH:26][CH:27]=[CH:28][C:17]=1[F:16])([OH:24])=[O:23]

Participants

3

Reactant 2

HCID 94652-FluorophenylalanineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 131730020HCID 131730020, compoundYield 58%

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-fluoro-DL-phenylalanine to provide the title compound in 58% yield as yellow needles (recrystallization from MeOH/NH4OH).

Sources & evidence

ORD record
ord-ef6ad6397eac44619f5aaeda445d22f6
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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