D-Phenylalanine → HCID 45254943, compound

HRID 2065628Notes

Reaction equation

Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:15][C@@H:16]([C:24]([OH:26])=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:24]([C@H:16]([NH:15][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([OH:26])=[O:25]

Participants

Reactant 2

HCID 71567D-Phenylalanine

HCID 8471632-Chloroquinoline-3-carboxylic acid

Product 1

HCID 45254943HCID 45254943, compound

Procedure

In close analogy to the procedure described in Example 1, 2-chloroquinoline-3-carboxylic acid is reacted with D-phenylalanine to provide the title compound in moderate yield.

Sources & evidence

ORD record: ord-2e0fa4f5ae3f41dc9bb0a99cb315317e
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288549B2

Reaction notes

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