D-Tryptophan → HCID 45254944, compound

HRID 2065629Notes

Reaction equation

HRID 2065629 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:15][C@@H:16]([C:27]([OH:29])=[O:28])[CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1>>[C:27]([C@H:16]([NH:15][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1)([OH:29])=[O:28]

Participants

3

Reactant 2

HCID 9060D-TryptophanHCID 8471632-Chloroquinoline-3-carboxylic acid

Product 1

HCID 45254944HCID 45254944, compound

Procedure

In close analogy to the procedure described in Example 1, 2-chloroquinoline-3-carboxylic acid is reacted with D-tryptophan to provide the title compound in moderate yield as yellow needles (recrystallization from isopropanol).

Sources & evidence

ORD record
ord-92c46ae77eb447c0b7eecde859fd3d01
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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