22976-70-1 → HCID 45255160, compound

HRID 2065636Notes

Reaction equation

HRID 2065636 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[C:16]([C:19]1[CH:30]=[CH:29][C:22]([CH2:23][CH:24]([C:26]([OH:28])=[O:27])[NH2:25])=[CH:21][CH:20]=1)([OH:18])=[O:17]>>[C:26]([CH:24]([NH:25][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:23][C:22]1[CH:29]=[CH:30][C:19]([C:16]([OH:18])=[O:17])=[CH:20][CH:21]=1)([OH:28])=[O:27]

Participants

3

Reactant 2

HCID 26527322976-70-1HCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45255160HCID 45255160, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 4-carboxy-DL-phenylalanine and crude product is separated by flash chromatography on SiO2 to provide the title compound in good yield.

Workup

  1. customis separated by flash chromatography on SiO2

Sources & evidence

ORD record
ord-a1b5ee2daaf14c548010279edd8b3ec4
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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