2,6-Dichloroquinoline-3-carboxylic acid → HCID 45255378, compound

HRID 2065638Notes

Reaction equation

HRID 2065638 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][N:22]1[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[N:23]1)[C:18]([OH:20])=[O:19]>>[C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][N:22]1[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[N:23]1)([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 53441648HCID 53441648, compound

Product 1

HCID 45255378HCID 45255378, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-(3,5-dimethyl-pyrazol-1-yl)-propionic acid to provide the title compound in good yield.

Sources & evidence

ORD record
ord-c3bfede214f34df5a08e0b181968779f
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

Loading…