2,6-Dichloroquinoline-3-carboxylic acid → HCID 45254945, compound

HRID 2065642Notes

Reaction equation

HRID 2065642 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[C:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:24][CH:23]=1)[C:18]([OH:20])=[O:19]>>[C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[C:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:24][CH:23]=1)([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 66649546HCID 66649546, compound

Product 1

HCID 45254945HCID 45254945, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-(4-phenylethynyl-phenyl)-propionic acid to provide the title compound in good yield.

Sources & evidence

ORD record
ord-d3fa9b4b8bbb49b6afa3b37f7d7a235c
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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