2,6-Dichloroquinoline-3-carboxylic acid → HCID 45255586, compound

HRID 2065647Notes

Reaction equation

HRID 2065647 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[Cl:16][C:17]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:18]=1[CH2:19][CH:20]([C:22]([OH:24])=[O:23])[NH2:21]>>[C:22]([CH:20]([NH:21][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:19][C:18]1[CH:25]=[C:26]([O:29][CH3:30])[CH:27]=[CH:28][C:17]=1[Cl:16])([OH:24])=[O:23]

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 67358730HCID 67358730, compound

Product 1

HCID 45255586HCID 45255586, compound

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-chloro-5-methoxy-DL-phenylalanine to provide the title compound in good yield.

Sources & evidence

ORD record
ord-5591f4fea6c14bf7bb5f32cfc0e3419c
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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