2,6-Dichloroquinoline-3-carboxylic acid → HCID 67358510, compound

HRID 2065651Notes

Reaction equation

HRID 2065651 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]([NH:24][CH:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH3:26])=[O:23])[C:18]([OH:20])=[O:19]>>[C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22](=[O:23])[NH:24][CH:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH3:26])([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 67359772HCID 67359772, compound

Product 1

HCID 67358510HCID 67358510, compound

Procedure

In close analogy to the procedure described in Example 32, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-N-(1-phenyl-ethyl)-succinamic acid to provide the title compound in good yield.

Sources & evidence

ORD record
ord-1e046d1471ce44829062823c790b3497
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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