2,6-Dichloroquinoline-3-carboxylic acid → HCID 67360581, compound

HRID 2065653Notes

Reaction equation

HRID 2065653 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:27][OH:28])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:19]>>[Cl:15][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:16][CH:17]([C:18](=[O:19])[NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:27][OH:28])[C:11]([C:12]([OH:14])=[O:13])=[CH:10]2

Participants

3

Reactant 2

HCID 242660682,6-Dichloroquinoline-3-carboxylic acidHCID 67359271HCID 67359271, compound

Product 1

HCID 67360581HCID 67360581, compound

Procedure

In close analogy to the procedure described in Example 43, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-hydroxy-N-phenyl-propionamide to provide the title compound in good yield. LCMS m/z 386 (M+1).

Sources & evidence

ORD record
ord-016f9375e80d46adb02cb64da44b2496
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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