HCID 4108624, compound → HCID 45255778, compound

HRID 2065655Notes

Reaction equation

HRID 2065655 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]1[N:23]=[CH:24][N:25]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[C:30]([CH3:37])[CH:29]=2)[CH:26]=1)[C:18]([OH:20])=[O:19]>>[C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22]1[N:23]=[CH:24][N:25]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[C:30]([CH3:37])[CH:29]=2)[CH:26]=1)([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 4108624HCID 4108624, compoundHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45255778HCID 45255778, compound

Procedure

In close analogy to the procedure described in Example 32, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-[1-(3-methyl-4-nitro-benzyl)-1H-imidazol-4-yl]-propionic acid to provide the title compound in good yield. LCMS m/z 510 (M+1).

Sources & evidence

ORD record
ord-7be6a486d689403d80a15445b76db596
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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