HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenylalanine → 2-[1-Carboxy-2-(3-fluoro-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenylalanine | HCID 9976 | — |
| Reactant | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-[1-Carboxy-2-(3-fluoro-phenyl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid | HCID 45256347 | — |
Reaction Steps
In close analogy to the procedure described in Example 32, 2,6-dichloro-quinoline-3-carboxylic acid is reacted with 3-fluoro-DL-phenylalanine in DMSO to provide the title compound in high yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-6c23a25debe24b9e810647b985342c9e |
| Source note | uspto-grants-2012_10 |