beta-(3-Pyridyl)-DL-alanine → HCID 45256348, compound

HRID 2065668Notes

Reaction equation

HRID 2065668 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)[C:18]([OH:20])=[O:19]>CS(C)=O>[C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 314100beta-(3-Pyridyl)-DL-alanineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 45256348HCID 45256348, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 32, 2,6-dichloro-quinoline-3-carboxylic acid is reacted with 2-amino-3-pyridin-3-yl-propionic acid in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-9122878d0cf64998a903bda1e2dc2796
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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