HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-2-chloroquinoline-3-carboxylic acid → 6-Bromo-2-{2-[4-(5-bromo-pyridin-2-yloxy)-phenyl]-1-carboxy-ethylamino}-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-2-chloroquinoline-3-carboxylic acid | HCID 24266072 | — |
| Reactant | 2-Amino-3-[4-(5-bromo-pyridin-2-yloxy)-phenyl]-propionic acid | HCID 67359928 | — |
| Product | 6-Bromo-2-{2-[4-(5-bromo-pyridin-2-yloxy)-phenyl]-1-carboxy-ethylamino}-quinoline-3-carboxylic acid | HCID 67359554 | — |
Reaction Steps
In close analogy to the procedure described in Example 109c, 6-bromo-2-chloroquinoline-3-carboxylic acid is reacted with 2-amino-3-[4-(5-bromo-pyridin-2-yloxy)-phenyl]-propionic acid (prepared by analogy to Example 109a,b) to provide the title compound in moderate yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4482a9f89df548a2bf57d8b5b6dee41d |
| Source note | uspto-grants-2012_10 |