4-Bromophenylalanine → HCID 67358284, compound

HRID 2065683Notes

Reaction equation

HRID 2065683 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][CH:23]=1)[C:18]([OH:20])=[O:19]>CS(C)=O>[Br:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][CH:17]([NH:16][C:2]2[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=3)[N:3]=2)[C:18]([OH:20])=[O:19])=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 856814-BromophenylalanineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67358284HCID 67358284, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-(4-bromo-phenyl)-propionic acid in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-67c788b529f84445afecad21c2d888d4
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

Loading…