L-Aspartic Acid → HCID 67358198, compound

HRID 2065684Notes

Reaction equation

HRID 2065684 reaction equation
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][C@H:17]([C:22]([OH:24])=[O:23])[CH2:18][C:19]([OH:21])=[O:20]>CS(C)=O>[OH2:13].[NH3:3].[C:12]([C:11]1[C:2]([NH:16][C@@H:17]([CH2:18][C:19]([OH:21])=[O:20])[C:22]([OH:24])=[O:23])=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([Cl:15])=[CH:6][CH:5]=2)([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 5960L-Aspartic AcidHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

Product 1

HCID 67358198HCID 67358198, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with L-aspartic acid in DMSO to provide the title compound in good yield.

Sources & evidence

ORD record
ord-798e859bf7024e678e1e0900160ad188
Source dataset
uspto-grants-2012_10
Patent number
US08288549B2

Reaction notes

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