HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-phenyl-succinic acid → 2-(3-Carboxy-6,8-dichloro-quinolin-2-ylamino)-3-phenyl-succinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-phenyl-succinic acid | HCID 310884 | — |
| Reactant | 2,6,8-Trichloroquinoline-3-carboxylic acid | HCID 86656379 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(3-Carboxy-6,8-dichloro-quinolin-2-ylamino)-3-phenyl-succinic acid | HCID 67357437 | — |
Reaction Steps
In close analogy to the procedure described in Example 1, 2,6,8-trichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-phenyl-succinic acid [J. Med. Chem. 1973, 16, 1277-1280.] in DMSO to provide the title compound in good yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9b25db7967b54784ad5404a2631b6554 |
| Source note | uspto-grants-2012_10 |