HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- → 2-{(S)-1-Carboxy-2-[4-(3-carboxy-6,8-dichloro-quinolin-2-yloxy)-phenyl]-ethylamino}-6,8-dichloro-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- | HCID 117439 | — |
| Reactant | 2,6,8-Trichloroquinoline-3-carboxylic acid | HCID 86656379 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-{(S)-1-Carboxy-2-[4-(3-carboxy-6,8-dichloro-quinolin-2-yloxy)-phenyl]-ethylamino}-6,8-dichloro-quinoline-3-carboxylic acid | HCID 67357883 | — |
Reaction Steps
In close analogy to the procedure described in Example 1, 2,6,8-trichloroquinoline-3-carboxylic acid is reacted with N-Boc-L-tyrosine in H2O to provide the title compound in good yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288549B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-24f0e85b5efc41f281c5cdb34bfdcded |
| Source note | uspto-grants-2012_10 |